（海洋科学：海洋化学）

一、个人概况

李志华，教授，理学博士，博士生导师。研究方向为海洋环境化学与生态毒理学。湖北省杰出青年基金获得者，入选武汉市青年科技晨光计划和中国水产科学研究院“百名英才”人才计划。主要学术兼职包括科技部国际合作专项评审专家库成员，国家自然基金委通讯评审专家等。目前担任SCI刊物Bulletin of Environmental Contamination and Toxicology的编委和BioMed Research International专刊的客座主编。先后主持国家级项目3课题，省部级项目5项，其他纵向课题4项，出版译著1部，发表SCI论文61篇，其中第一作者48篇，文章他引1145次，H-index=22。获得授权国家专利11项（其中第一发明人9项）。获得国家优秀自费留学生奖学金（2010）；南波西米亚大学优秀科技成果校长奖（2011）和首届中国水产青年科技奖（2016）。

二、主要研究与合作领域

1、水环境中典型污染物的生态毒性效应及分子机制研究，

2、水环境新兴污染物（如药物残留活性物质、人工纳米污染物等）的分子标记物的筛选及其环境健康风险评估

三、课题情况（近五年）

1、2016-2019，低剂量三丁基锡与镉联合暴露对鲤鱼内分泌轴线交互影响效应及作用机制研究（国家自然科学基金面上项目，31570511），主持人

2、2015-2017，温度对草鱼幼鱼在低剂量汞胁迫下毒代动力学及生理应答影响研究（国家自然科学基金青年项目，21407181），主持人

3、2018-2022，重要渔业种群动态长期变化特征及生态适应性（国家重点研发计划项目课题，2018YFD0900902），子课题主持人

4、2018-2020，环境激素三丁基锡的分子毒理学及生物标志物筛选（湖北省自然科学基金杰出青年项目，2017CFA071），主持人

5、2015-2016，不同温度下草鱼幼鱼对汞胁迫的耐受性研究（湖北省自然科学基金面上项目，2014CFB266），主持人

6、2015-2019，典型化学物污染淡水水产品质量安全综合防治技术方案（子课题）（公益性行业（农业）科研专项经费项目，201503108-CC-1），共同主持人

7、2017-2019，环境激素三苯基锡内分泌干扰跨代效应研究（武汉市青年科技晨光计划，2017050304010273），主持人

8、2014-2016，环境激素三丁基锡对鲤鱼的危害及其机制（中国水产科学研究院基本科研业务费，2014A02YQ01），主持人

四、代表性论文、专著

As the first author

1、Li Z.H*., Li P.*, Shi Z.C. 2016.Chronic effects of tributyltin on multiple biomarkers responses in juvenile common carp, Cyprinus carpio. Environmental Toxicology, 31(8):937-944.

2、Li Z.H*., Zhong L.Q., Mu W.N. Wu Y.H. 2016.Effects of chronic exposure to tributyltin on tissue-specific cytochrome P450 1 regulation in juvenile common carp. Xenobiotica. 46(6):511-515.

3、Li Z.H*., Li P., Shi Z.C. 2016.Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin. Environmental Toxicology，31(3):278-284.

4、Li Z.H*., Zhong L.Q., Mu W.N. Wu Y.H. 2016. Toxicity of tributyltin in juvenile common carp (Cyprinus carpio): physiological responses, hepatic gene expression and stress protein profiling. Journal of Biochemical and Molecular Toxicology, 30(2):91-96.

5、Li Z.H*., Zhong L.Q., Mu W.N. Wu Y.H. 2016. Alteration of cytochrome P450 1 regulation and HSP 70 level in brain of juvenile common carp (Cyprinus carpio) after chronic exposure to tributyltin. Fish Physiology and Biochemistry, 42(1):287-294.

6、Li Z.H*., He K., Liu C., Li P., Zlabek V., 2016. Aquatic Environmental Health and Toxicology. BioMed Research International, 2016 (2016), Article ID 3514898.

7、Li Z.H*., Zhong L.Q., Mu W.N. Wu Y.H. 2016. Alteration of parameters of energy metabolism and ATPase enzymatic system in juvenile common carp (Cyprinus carpio) chronically exposed to tributyltin, Czech Journal of Animal Science, 61(7):326-332.

8、Li Z.H*.,Wu Y.H., Li P., Li Y.F., Ni Z.H. 2015.Alterationof antioxidant response and expression of related genes by Cadmium in Chinese rare minnow larvae. CLEAN - Soil, Air, Water, 43(5), 671–675

9、Li Z.H*., Li P., Shi Z.C. 2015.Chronic exposure to tributyltin induces brain functional damage in juvenile common carp (Cyprinus carpio) PLoS ONE, 10(4), e0123091.

10、Li Z.H*., Li P.,& Shi Z.C. 2015.Responses of the hepatic glutathione antioxidant defense system and related gene expression in juvenile common carp after chronic treatment with tributyltin. Ecotoxicology, 24, 700-705.

11、Li, Z.H*., Li, P. 2015. Evaluation of tributyltin toxicity in Chinese rare minnow larvae by abnormal behavior, energy metabolism and endoplasmic reticulum stress. Chemico-Biological Interactions, 227, 32–36

12、Li, Z.H*., Li, P., Chen, L., 2014. Temperature affects Hg-induced antioxidant responses in Chinese rare minnow Gobiocypris rarus larvae in vitro. Bulletin of Environmental Contamination and Toxicology,93, 666-669.

13、Li Z.H*., Li P., Shi Z.C. 2014. Molecular responses in digestive tract of juvenile common carp after chronic exposure to sublethal tributyltin. Ecotoxicology and Environmental Safety, 109, 10-14.

14、Li Z.H*., Chen L., Wu Y.H., Li P., Li Y.F., Ni Z.H.* 2014. Effects of mercury on oxidative stress and gene expression of potential biomarkers in larvae of the Chinese rare minnow Gobiocypris Rarus. Archives of Environmental Contamination and Toxicology, 67, 245-251.

15、Li Z.H*., Chen L., Wu Y.H., Li P., Li Y.F., Ni Z.H.* 2014. Alteration of thyroid hormone levels and related gene expression in Chinese rare minnow larvae exposed to mercury chloride. Environmental Toxicology and Pharmacology, 38, 325-331.

16、Li Z.H*., Chen L., Wu Y.H., Li P., Li Y.F., Ni Z.H.* 2014. Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 161, 53-57.

17、Li, Z.H., Xu, H.Y., Zheng, W.L., Lam, S.H., Gong, Z.Y*. 2013. RNA-sequencing analysis of TCDD-induced responses in zebrafish liver reveals high relatedness to in vivo mammalian models and conserved biological pathways. PLoS ONE, 8(10): e77292.

18、Li, Z.H.*, Zlabek, V., Velisek, J., Grabic, R., Machova, J., Kolarova, J., Li, P., Randak, T. 2013. Multiple biomarkers responses in juvenile rainbow trout, Oncorhynchus mykiss, after acute exposure to a fungicide propiconazole. Environmental Toxicology 28(3):119-126.

19、Li, Z.H.*, Li, P.*, Sulc, M., Hulak, M., Randak, T., 2012. Hepatic proteome sensitivity in rainbow trout after chronically exposed to a human pharmaceutical Verapamil. Molecular and Cellular Proteomics, 11(1): M111.008409.

20、Li Z.H.*, Li P., Randak T. 2011. Protective roles of calcium channel blocker against cadmium-induced physiological stress in freshwater teleost Oncorhynchus mykiss. Water, Air, & Soil Pollution 220 (1-4):293-299.

21、Li, Z.H.*, Li, P., Randak, T. 2011. Evaluating the toxicity of environmental concentrations of waterborne chromium (VI) to a model teleost, Oncorhynchus mykiss: a comparative study of in vivo and in vitro. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 153(4): 402-407.

22、Li Z.H.*, Velisek J., Grabic R., Li P., Kolarova J., Randak T. 2011. Use of hematological and plasma biochemical parameters to assess the chronic effects of a fungicide Propiconazole on a freshwater teleost. Chemosphere, 83(4): 572-578.

23、Li, Z.H.*, Zlabek, V., Li, P., Grabic, R., Velisek, J., Machova, J., Randak, T., 2011. Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): effects on antioxidant responses, hematological parameters and hepatic EROD. Ecotoxicology and Environmental Safety 74 (3): 319-327.

24、Li, Z.H.*, Zlabek, V., Grabic, R., Li, P., Randak, T., 2011. Biochemical responses in gill of rainbow trout exposed to propiconazole. Central European Journal of Biology 6 (1): 84-90.

25、Li, Z.H.*, Velisek, J., Zlabek, V., Grabic, R., Machova, J., Kolarova, J., Li, P., Randak, T., 2011. Chronic toxicity of Verapamil on juvenile rainbow trout (Oncorhynchus mykiss): effects on morphological indices; hematological parameters and antioxidant responses. Journal of Hazardous Materials 185 (2-3): 870-880.

26、Li, Z.H.*, Zlabek, V., Velisek, J., Grabic, R., Machova, J., Kolarova, J., Li, P., Randak, T., 2011. Antioxidant responses and plasma biochemical characteristics in the freshwater rainbow trout, Oncorhynchus mykiss, after acute exposure to the fungicide propiconazole. Czech Journal of Animal Science 56(2):64-72.

27、Li, Z.H.*, Zlabek, V., Turek, J., Velisek, J., Pulkrabova, J., Kolarova, J., Sudova, E., Berankova, P., Hradkova, P., Hajslova, J., Randak, T., 2011. Evaluating environmental impact of STPs situated on streams in the Czech Republic: An integrated approach to biomonitoring the aquatic environment. Water Research 45 (3): 1403-1413.

28、Li, Z.H.*, Li, P., Dzyuba, B., Randak, T., 2010. Influence of environmental related concentrations of heavy metals on motility parameters and antioxidant responses in sturgeon sperm. Chemico-Biological Interactions 188(3): 473-477.

29、Li, Z.H.*, Li, P, Rodina, M, Randak, T., 2010. Evaluating the function of calcium antagonist on the cadmium-induced stress in sperm of Russian sturgeon, Acipenser gueldenstaedtii. Aquatic Toxicology 100(4): 373-375.

30、Li, Z.H.*, Li, P., Randak, T., 2010. Effect of a human pharmaceutical carbamazepine on antioxidant responses in brain of a model teleost in vitro: An efficient approach to biomonitoring. Journal of Applied Toxicology 30(7): 644-648.

31、Li, Z.H.*, Li, P., Randak, T., 2010. Ecotoxocological effects of short-term exposure to a human pharmaceutical Verapamil in juvenile rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 152(3): 385-391.

32、Li, Z.H.*, Zlabek, V., Grabic, R., Li, P., Randak, T., 2010. Modulation of glutathione-related antioxidant defense system of fish, chronically treated by the fungicide propiconazole. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 152(3): 392-398.

33、Li, Z.H.*, Zlabek, V., Li, P., Grabic, R., Velisek, J., Machova, J., Randak, T., 2010. Biochemical and physiological responses in liver and muscle of rainbow trout after long-term exposure to propiconazole. Ecotoxicology and Environmental Safety 73(6): 1391-1396.

34、Li, Z.H.*, Zlabek, V., Grabic, R., Li, P., Machova, J., Velisek, J., Randak, T., 2010. Effects of exposure to sublethal propiconazole on the antioxidant defense system and Na+-K+-ATPase activity in brain of rainbow trout, Oncorhynchus mykiss. Aquatic Toxicology 98(3): 297-303.

35、Li, Z.H.*, Li, P, Rodina, M, Randak, T., 2010. Effect of human pharmaceutical Carbamazepine on the quality parameters and oxidative stress in common carp (Cyprinus carpio L.) spermatozoa. Chemosphere 80(5): 530-534.

36、Li, Z.H.*, Velisek, J., Zlabek, V., Grabic, R., Machova, J., Randak, T., 2010. Enzymatic alterations and RNA/DNA ratio in intestine of rainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine. Ecotoxicology 19(5): 872–878.

37、Li, Z.H.*, Zlabek, V., Grabic, R., Li, P., Machova, J., Velisek, J., Randak, T., 2010. Effects of exposure to sublethal propiconazole on intestine-related biochemical responses in rainbow trout, Oncorhynchus mykiss. Chemico-Biological Interactions 185(3): 241-246.

38、Li, Z.H.*, Zlabek, V., Velisek, J., Grabic, R., Machova, J., Randak, T., 2010. Physiological condition status and muscle-based biochemical responses in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine. Journal of Applied Toxicology 30(3): 197-203.

39、Li, Z.H.*, Velisek, J., Zlabek, V., Grabic, R., Machova, J., Kolarova, J., Randak, T., 2010. Hepatic antioxidant status and haematological parameters in rainbow trout, Oncorhynchus mykiss, after chronic exposure to carbamazepine. Chemico-Biological Interactions 183(1): 98-104.

40、Li, Z.H.*, Zlabek, V., Velisek, J., Grabic, R., Machova, J., Randak, T., 2010. Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 151(1): 137-141.

41、Li, Z.H.*, Zlabek, V., Velisek, J., Grabic, R., Machova, J., Randak, T., 2009. Responses of antioxidant status and Na+-K+-ATPase activity in gill of rainbow trout, Oncorhynchus mykiss, chronically treated with carbamazepine. Chemosphere 77(11):1476-1481.

42、Li, Z.H., Xie, S., Wang, J.X., Sales, J., Li, P., Chen, D.Q.*, 2009. Effect of intermittent starvation on growth and some antioxidant indexes of Macrobrachium nipponense (De Haan). Aquaculture research 40(5): 526-532.

43、Li, Z.H.*, Randak, T., 2009. Residual pharmaceutically active compounds (PhACs) in aquatic environment: status, toxicity and kinetics. Veterinarni Medicina 52 (7): 295-314.

As corresponding author

44、Wu Y.H, Li Z.H*., Zhong L.Q. Chen D.Q. 2016. Tissue-specific stress and hepatic DNA damage in Pelteobagrus fulvidraco caused by low concentrations of cadmium. Toxicological & Environmental Chemistry. 98(1):90-100.

45、Mu W.N, Li Z.H*., Zhong L.Q. Wu Y.H. 2016 Effect of tributyltin, cadmium and their mixture on physiological responses in juvenile grass carp, Ctenopharyngodon idella, Journal of Aquatic Animal Health, 28(3):181-186.

46、Li P. Li Z.H*. 2015. Physiological responses in Chinese rare minnow larvae following exposure to low-dose tributyltin. Bulletin of Environmental Contamination and Toxicology, 95:588–592.

47、Li, P.*, Li, Z.H.*, Hulak, M., Rodina, M., Linhart, O., 2012. Regulation of spermatozoa motility in response to cations in Russian sturgeon (Acipenser gueldenstaedtii). Theriogenology 78(1): 102-109 (* corresponding author)

As co-auhor

48、Lui E.Y., Li C., Li Z.H., Gong Z., Lam S.H. 2016 Molecular insights of organochlorine biocide-induced toxicity in zebrafish: Whole-adult-organism toxicogenomics, targeted gene expression and histological analyses. Journal of Genetics and Genomics 43(8):525-528.

49、Velisek, J*, Svobodova, Z, Kouba, A, Li, Z.H. 2014 .Fish and Crayfish Toxicology. BioMed Research International, Article Number: 768689

50、Lam, S.H., Ung. C.Y., Hlainga, M.M., Hu, J., Li, Z.H., Mathavanc, S., Gong, Z.Y*. 2013. Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: Transcriptomic, histological and targeted gene expression analyses. Biochimica et Biophysica Acta (BBA) - General Subjects 1830(10): 4778–4789

51、Li, P., Hulak, M., Li, Z.H., Sulc, M., Psenicka, M., Rodina, M., Gela, D., Linhart, O. 2013. Cryopreservation of common carp (Cyprinus carpio L.) sperm induces protein phosphorylation in tyrosine and threonine residues. Theriogenology 80(2): 84-89.

52、Burkina, V., Zamaratskaia, G., Randak, T., Li, Z.H., Fedorova, G., Pickova, G., Zlabek, V., 2012. Verapamil does not modify catalytic activity of CYP450 in rainbow trout after long-term exposure. Ecotoxicology and Environmental Safety 79(1): 148-152.

53、Li, P., Rodina, M, Hulak, M., Li, Z.H., Linhart, O., 2011. Spermatozoa concentration, seminal plasma composition and their physiological relationship in the endangered stellate sturgeon (Acipenser stellatus) and Russian sturgeon (Acipenser gueldenstaedtii). Reproduction in Domestic Animals 46(2): 247–252.

54、Li, P., Rodina, M., Hulak, M., Gela, D., Psenicka, M., Li, Z.H., Linhart, O., 2011. Physico-chemical properties and protein profiles of sperm from three freshwater chondrostean species: a comparative study among Siberian sturgeon (Acipenser baerii), sterlet (Acipenser ruthenus) and paddlefish (Polyodon spathula). Journal of Applied Ichthyology 27(2): 673–677.

55、Velisek, J., Stara, A., Li, Z.H., Silovska, S., Turek, J. 2011. Comparison of the effects of four anaesthetics on biochemical blood profile and oxidative stress biomarkers of rainbow trout. Aquaculture 310 (3-4): 369-375.

56、Li, P., Hulak, M., Rodina, M., Sulc, M., Li, Z.H., Linhart, O., 2010. Comparative protein profiles: potential molecular markers from spermatozoa of Acipenseriformes (Chondrostei, Pisces). Comparative Biochemistry and Physiology: Part D: Genomics and Proteomics 5(4): 302-307.

57、Li, P., Li, Z.H., Dzyuba, B., Hulak, M., Rodina, M., Linhart, O., 2010. Evaluating the impacts of osmotic and oxidative stress on common carp (Cyprinus carpio, L.) sperm caused by cryopreservation techniques. Biology of Reproduction 83(5): 852-858.

58、Li, P., Dzyuba, B., Hulak, M., Rodina, M., Boryshpolets, S., Li, Z.H., Linhart, O., 2010. Percoll gradient separation of cryopreserved common carp spermatozoa to obtain a fraction with higher motility, velocity and membrane integrity. Theriogenology 74(8): 1356-1361.

59、Li, P., Rodina, M., Hulak, M., Gela, D., Li, Z.H., Linhart, O., 2010. Physico-biochemical parameters and protein profiles of sperm from beluga Huso huso. Journal of Applied Ichthyology 26(5): 753-755.

60、Duan, X.B., Liu, S.P., Huang, M.G., Qiu, S.L., Li, Z.H., Wang, K., Chen, D.Q., 2009. Changes in abundance of larvae of the four domestic Chinese carps in the middle reach of the Yangtze River, China, before and after closing of the Three Gorges Dam. Environmental Biology of Fishes 86(1):13-22.

61、Wang, W.N., Wang, A.L., Zhang, Y.J., Li, Z.H., Wang, J.X., Sun, R.Y. 2004. Effects of nitrite on lethal and immune response of Macrobrachium nipponense. Aquaculture 232 (1-4): 679-686.

五、获奖情况

1、南波西米亚大学渔业与水保护学院35岁以下青年优秀科研成果一等奖，2009；

2、国家优秀自费留学生奖学金，2010；

3、南波西米亚大学优秀科技成果校长奖，2011。

4、中国水产青年科技奖，2016。

六、联系方式

1、邮箱：lizh@sdu.edu.cn，lzhyfi@126.com

2、电话：0631-5682526